[PDF][PDF] Computational Drug Repurposing Resources and Approaches for Discovering Novel Antifungal Drugs against Candida albicans N-Myristoyl Transferase.
A Hussain, CK Verma - Journal of Pure & Applied …, 2021 - pdfs.semanticscholar.org
… and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and
… ICM-a new method for protein modeling and design: applications to docking and structure …
… ICM-a new method for protein modeling and design: applications to docking and structure …
[HTML][HTML] Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity
… inhibitors have been reported: (a) peptidomimetic inhibitors [6… site 2 in N-Myristoyltransferase
binds with myristoyl-COA and … have reported a pseudo-peptidic NMT inhibitor with an IC 50 …
binds with myristoyl-COA and … have reported a pseudo-peptidic NMT inhibitor with an IC 50 …
Rational design, synthesis, analysis and antifungal activity of novel myristic acid derivatives as N-myristoyltransferase inhibitors
S Javid, D Shanmugarajan, HY Kumar… - Journal of Molecular …, 2024 - Elsevier
… of the myristoyl group of myristoyl-CoA to the N-terminal … of NMT inhibitors that have been
reported (a) peptidomimetic … docking was validated with bound peptidic inhibitor (MIM) to …
reported (a) peptidomimetic … docking was validated with bound peptidic inhibitor (MIM) to …
[HTML][HTML] Drug discovery in leishmaniasis using protein lipidation as a target
JA Brannigan, AJ Wilkinson - Biophysical Reviews, 2021 - Springer
… Here, we review investigations into N-myristoyltransferase (NMT… amino terminal peptide
segment of the substrate protein or, … ) with myristoyl-CoA and a peptidomimetic inhibitor bound in …
segment of the substrate protein or, … ) with myristoyl-CoA and a peptidomimetic inhibitor bound in …
Selective Bias Virtual Screening for Discovery of Promising Antimalarial Candidates targeting Plasmodium N-Myristoyltransferase
C Andrade, BK de Paula Sousa, S Sigurdardóttir… - 2024 - researchsquare.com
… N-myristoyltransferase with bound myristoylCoA and peptide … pharmacophore for Candida
albicans MyristoylCoA: protein … Peptidomimetic inhibitors of N-myristoyltransferase from …
albicans MyristoylCoA: protein … Peptidomimetic inhibitors of N-myristoyltransferase from …
[HTML][HTML] Molecular targets for antifungals in amino acid and protein biosynthetic pathways
A Kuplińska, K Rząd - Amino Acids, 2021 - Springer
… of antifungal drugs, decreasing their prices and reducing side effects. Searching for novel
approaches in this respect, amino acid and protein … selective drug candidates with a different …
approaches in this respect, amino acid and protein … selective drug candidates with a different …
[HTML][HTML] High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation
C Dian, I Pérez-Dorado, F Rivière, T Asensio… - Nature …, 2020 - nature.com
… N-myristoyltransferase (NMT) catalyses an essential protein … contributes to peptide acceptor
site formation together with C-… an important role in peptide selectivity and catalysis and is …
site formation together with C-… an important role in peptide selectivity and catalysis and is …
Exploring N-myristoyltransferase as a promising drug target against parasitic neglected tropical diseases
IJ dos Santos Nascimento, MAT Cavalcanti… - European Journal of …, 2023 - Elsevier
… N-myristoyltransferase and with the highest target selectivity. … require NMT and the
myristoyl-CoA substrate to catalyze the … transferred to the protein by attacking the peptide …
myristoyl-CoA substrate to catalyze the … transferred to the protein by attacking the peptide …
Fungal acetyltransferases structures, mechanisms and inhibitors: a review
… group from myristoyl-CoA is catalytically transferred to peptide. … Catalytic mechanism of
N-myristoyltransferase Nmt1p of S. … is a peptidomimetic inhibitor of NMT designed from peptide …
N-myristoyltransferase Nmt1p of S. … is a peptidomimetic inhibitor of NMT designed from peptide …
[HTML][HTML] Protein lipidation in health and disease: molecular basis, physiological function and pathological implication
Y Yuan, P Li, J Li, Q Zhao, Y Chang, X He - … and Targeted Therapy, 2024 - nature.com
… N-myristoylation was first reported in 1982, 15 and is catalysed by N-myristoyltransferase
(NMT). Approaches for detecting protein N-myristoylation include radioactive-labelled fatty …
(NMT). Approaches for detecting protein N-myristoylation include radioactive-labelled fatty …